Oxidative stress and mitochondrial dysfunction are major events leading to nerve cell death. Oxidative stress and related mitochondrial dysfunction is one of the common cooperative sharing pathways involved in neurodegenerative disorders including Huntington's disease. Flavonoids have well known antioxidant activity. Diosmin is a flavone, a member of the flavonoid family, resemble the structure of oestrogen and display agonistic interactions with the oestrogen receptor. Oestrogen and diosmin is reported to be a neuroprotective antioxidant. Systemic 3-nitropropionic acid (10 mg/kg/i.p) treatment for 14 days in rats significantly induced huntington’s disease like symptoms in rats as indicated by reduced locomotor activity, body weight, grip strength, cognition, oxidative defense and mitochondrial enzymes (complex-I, -II and lactate dehydrogenase) activities in striatum. The effect of diosmin on 3 nitropropionic acid oxidative stress and mitochondrial enzyme activities was investigated. Treatment with diosmin (5, 10 and 15 mg/kg/oral) significantly reversed behavioral, biochemical enzyme dysfunctions in 3-nitropropionic acid treated group.
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